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Most proteins that bind to DNA do so by recognizing a distinct nucleotide sequence. The bacterial protein DnaA binds to DNA at several places in the genome using this conventional mechanism, but additionally associates with DNA at many additional loci by piggybacking on Rok, another DNA binding protein. DnaA stimulates the ability of Rok to bind DNA and together, these two proteins appear to modulate expression of several genes.
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This page is a summary of: Genetic and biochemical interactions between the bacterial replication initiator DnaA and the nucleoid-associated protein Rok inBacillus subtilis, Molecular Microbiology, January 2017, Wiley,
DOI: 10.1111/mmi.13590.
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