A PTS EII mutant library in Group A Streptococcus identifies a promiscuous man‐family PTS transporter influencing SLS ‐mediated hemolysis

What is it about?

Several sugar transporters (Enzyme IICs, EIIC) contribute to the timely expression of the toxin Streptolysin S (SLS), and are redundant for the transport of sugars. The Mannose-specific EII plays an important role in GAS for both PTS carbohydrate metabolism and Streptolysin S expression, potentially allowing for GAS to extract nutrients from the host in order to survive. Black dashed arrows represent the influence of EIIs and other components of carbon metabolism on SLS production.

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