Structural basis for the transcriptional repressor NicR2 in nicotine degradation fromPseudomonas

What is it about?

NicR2 contains a pocket to selectively recognize its inducer, thus unties the transcription of nic2 cluster. The key residues from both HTH motif and N-terminal extension of NicR2 participate in the association with DNA and repress the transcription of nic2 cluster. Our structural and biochemical investigations unravel how NicR2 selectively recognizes HSP and DNA, and provide new insights into the TetR family of repressors.

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