Staphylococcus aureusSufT: an essential iron-sulphur cluster assembly factor in cells experiencing a high-demand for lipoic acid

What is it about?

Cells contain iron-sulfur (Fe-S) cluster utilizing proteins and proteins that facilitate cluster assembly. Lipoic acid (LA) is a product of the Fe-S cluster dependent enzyme LipA. The SufT Fe-S cluster assembly factor is essential in cells experiencing a high demand for lipoamide-dependent enzymes. We propose that the demand for products of Fe-S enzymes is a factor governing the usage of one Fe-S assembly factor over another in the maturation of apo-proteins.

Featured Image