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Like many other bacteria, the human pathogen Vibrio cholerae is able to combat reactive oxygen species (ROS). We found that V. cholerae virulence regulator AphB works together with organic hydroperoxide resistance regulator OhrR to regulate ROS resistance through OhrA. AphB and OhrR respond to redox potentials differently so that they fine-tune ohrA expression to better adapt various environmental niches.
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This page is a summary of: Thiol-based switch mechanism of virulence regulator AphB modulates oxidative stress response inVibrio cholerae, Molecular Microbiology, October 2016, Wiley,
DOI: 10.1111/mmi.13524.
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