AvaR2, a pseudo γ-butyrolactone receptor homologue fromStreptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth

What is it about?

The autoregulator that triggers avermectin biosynthesis in <i>Streptomyces avermitilis</i> is butenolide-type avenolide. We identified AvaR2, a pseudo γ-butyrolactone receptor homologue, as an important repressor of avermectin and avenolide biosynthesis and cell growth, and also as a receptor of endogenous avenolide and exogenous antibiotics. Our findings clarify and extend the regulatory mechanisms of avermectin biosynthesis, and the ecological significance of antibiotics as signals for <i>Streptomyces</i> interspecies communication to induce cellular responses mediated by pseudo GBL receptors.

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