What is it about?
Angiopoietin‐like 4 is a key factor in the regulation of blood vessel fromation and bone resorption. The role of angiopoietin‐like 4 in periodontal tissue is currently unknown. Here, we show that hypoxia and the hypoxia mimetic agent L‐mimosine increase angiopoietin‐like 4 produktion in periodontal fibroblasts.
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Why is it important?
Periodontal diseases is not properly treated can lead to tooth loss. In osteolytic diseases angiopoietin‐like 4 was identified as a key player in bone resorption. The role of angiopoietin‐like 4 in oral tissue and the destruction of the periodont is unclear. It is therefore of clinical relefance to reveal the meachanisms underlying the regulation of angiopoietin‐like 4 in periodontal health and disease.
Perspectives
What was really interesting for me was that the response of the cells depends on the culture model chosen for the assays. This highlights the importance of choosing the right in vitro model.
Priv.-Doz. Hermann Agis
Medizinische Universitat Wien
Read the Original
This page is a summary of: Angiopoietin‐like 4 production upon treatment with hypoxia and L‐mimosine in periodontal fibroblasts, Journal of Periodontal Research, March 2019, Wiley,
DOI: 10.1111/jre.12649.
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