What is it about?
Basics for understanding when the precursor of melatonin could be the darkness hormone. Opening new avenues for exploring the timing of the organism in pathophysiological conditions.
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Why is it important?
It opens the possibility of understanding how the whole organism could distinguish between necrosis of cells in the brain, or a huge increase in ATP around the pineal gland, and signaling a microbial infection.
Perspectives
As N-acetylserotonin plays cell protector role in the brain and liver, and impairs the expression of adhesion molecules in endothelial cells, this work points to a new role for the pineal gland when necroptic, apoptotic and death cells release high amount of ATP in the CSF.
Professor Regina P Markus
University of São Paulo, Brazil.
Read the Original
This page is a summary of: Adenosine triphosphate inhibits melatonin synthesis in the rat pineal gland, Journal of Pineal Research, January 2016, Wiley,
DOI: 10.1111/jpi.12309.
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