What is it about?
Wistar rats treated with intra-cerebral injection of Paraquat revealed, at central level, an increase of malondialdehyde (MDA), an important marker of lipid peroxidation and superoxide radical species. We validated an HPLC method to detect free and total MDA on homogenate rat brain. MDA was derivatized with DNPH to produce hydrazone that was purified by solid phase extraction SPE.
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Why is it important?
We showed that both natural and semisynthetic polyphenol derivatives from Olea Europea L. were able to reduce MDA detection. The more lipophilic acetyl-derivatives showed an antioxidant activity greater then parent compounds. This potency seems to put in evidence a strict correlation between lipophilicity and bioavailability. Then, various lipophilic compounds have been synthesized using a simple and environmentally friendly semisynthetic protocol by chemical manipulation of complex natural substances.
Perspectives
Because a major lipophilic character can help to ensure improved biological availability of the molecules, acetylated compounds may exert a better protective action than their hydrophilic analogues. These species are proposed as pro-active compound, supposed to better cross the blood brain barrier and biochemically be converted in vivo into their original active forms.
Milena Rizzo
UNIVERSITY OF CATANIA, ITALY
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This page is a summary of: Antioxidant activity of oleuropein and semisynthetic acetyl-derivatives determined by measuring malondialdehyde in rat brain, Journal of Pharmacy and Pharmacology, September 2017, Wiley,
DOI: 10.1111/jphp.12807.
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