What is it about?
Oral cancer is the sixth most common malignancy in the world. Despite numerous advances in treatment, the 5-year survival has remained at 50% for the last 50 years. About 10–15% of all oral cancers are known to be caused by viruses.
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Why is it important?
Literature research on association of oral cancer with EBV is contentious and is dependent on various factors such as geographical/regional variations, sociocultural lifestyles, dietary habits, and chewing/smoking tobacco habit. Many Asian studies found a high prevalence of EBV whereas many North American and European studies have reported lower prevalence . Therefore, this study was designed to investigate the immunohistochemical expression of EBV in oral cancer among South Indian tobacco-chewing population in order to elucidate the involvement of EBV in oral carcinogenesis and to know whether EBV can be a valuable diagnostic and prognostic indicator.
Perspectives
Literature search results are conflicting and dependent on various factors such as geographical/regional variations, sociocultural lifestyles, dietary habits, chewing/smoking tobacco habit. This study is the first original observation about frequency of Epstein–Barr virus among South Indian tobacco-chewing patients to elucidate its involvement in oral carcinogenesis and to know whether this can be a valuable diagnostic and prognostic indicator.
Dr SHIVANI SHARMA
Read the Original
This page is a summary of: Expression of Epstein-Barr virus among oral potentially malignant disorders and oral squamous cell carcinomas in the South Indian tobacco-chewing population, Journal of Oral Pathology and Medicine, November 2016, Wiley,
DOI: 10.1111/jop.12508.
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