What is it about?
C. albicans ADH1 has the ability to convert ethanol to acetaldehyde, a known carcinogen. We investigated the relationship between expression of Candida albicans alcohol dehydrogenases (ADH) genes in human archival biopsy samples diagnosed as chronic hyperplastic candidosis (CHC).
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Why is it important?
Candida albicans was the predominant species in the lesions diagnosed as CHC. In the presence of ethanol, C. albicans ADH1 can convert ethanol to acetaldehyde, a known carcinogen. CHC has a propensity for malignant transformation and therefore CHC lesions should be monitored.
Perspectives
Candida infection has been associated with oral leukoplakias potentially malignant oral disorders (PMOD) since the 1960s. Although there was no association between the presence of Candida and malignant transformation in the cases examined, it was noted that the number of cases was limited and further studies are needed to further elucidate the role of C. albicans ADH1 in the pathogenesis of oral squamous cell carcinoma.
Marina M Bakri
University of Malaya
Read the Original
This page is a summary of: Detection ofCandida albicans ADH1andADH2mRNAs in human archival oral biopsy samples, Journal of Oral Pathology and Medicine, June 2014, Wiley,
DOI: 10.1111/jop.12193.
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