What is it about?
Clomiphene citrate has been used in IVF before. Either alone or sequentially after gonadotropins. While these regimens are known to reduce costs, they have not proven to be as effective as conventional high dose gonadotropins in effecting live births. This is especially true for the non poor responder. This study proves that simultaneous instead of sequential addition of clomiphene citrate to gonadotropins helps in lowering gonadotropin consumption, while being equally effective across different response categories in terms of fresh cycle IVF outcomes and total live births per started cycle.
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Why is it important?
The study suggests that cost lowering in IVF without affecting fresh cycle or cumulative outcomes is possible by adding Clomiphene citrate to the conventional antagonist regimes. The cost reduction is entirely due to lowered gonadotropin consumption.
Perspectives
This work is the result of careful and meticulous collection of data generated through our work. We have had an earlier publication (2014) on cost reduction due to use of continuous Clomiphene citrate in commercial egg donors.
Ruma Satwik
Sir Ganga Ram Hospital
Read the Original
This page is a summary of: Effect of simultaneously started clomiphene citrate and gonadotropins in antagonist regimes, on cumulative live births, fresh-cycle live births and cost of stimulation in IVF cycles, Journal of Obstetrics and Gynaecology Research, April 2018, Wiley,
DOI: 10.1111/jog.13624.
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