What is it about?
Increased levels of C19MC microRNAs in maternal plasma are a characteristic phenomenon of established severe pre-eclampsia. This study demonstrated for the first time that the up-regulation of C19MC miRNAs occurred as a consequence of, not in advance of, the onset of pre-eclampsia.
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Why is it important?
We confirmed that circulating levels of C19MC miRNAs in maternal plasma is a characteristic phenomenon of established severe pre-eclampsia, and demonstrated for the first time that the up-regulation of C19MC miRNAs occurred as a consequence of, not in advance of, the onset of pre-eclampsia.
Perspectives
Circulating C19MC miRNAs in maternal plasma seem to play a fundamental role in a variety of physiological and pathological processes involving preeclampsia. To clarify the high biological variability of PE, future studies regarding the roles of differentially expressed circulating C19MC miRNAs in PE patients will further our understanding of the pathogenesis of this disease, and contribute to its diagnosis and management.
Kiyonori Miura
Nagasaki Daigaku
Read the Original
This page is a summary of: Circulating chromosome 19 miRNA cluster microRNAs in pregnant women with severe pre-eclampsia, Journal of Obstetrics and Gynaecology Research, July 2015, Wiley,
DOI: 10.1111/jog.12749.
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