What is it about?
This multi-institutional prospective cohort study investigated the risk of progression of CIN2 with various combinations of high risk (HR)-HPV and low risk (LR)-HPV infection.
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Why is it important?
CIN 2 progression was positively associated with HPV16 infection and CIN2 regression was negatively associated with HPV16 infection. CIN2 progression was negatively associated with LR-HPV co-infection (hazard ratio = 0.152; 95% confidence interval [CI] = 0.042–0.553), and CIN2 regression was positively associated with LR-HPV co-infection (odds ratio = 4.553; 95%CI = 1.378–15.039) with adjustment for the presence of HPV16 infection.
Perspectives
This study shows, for the first time, that CIN2 tends to regress when women have combined infection of HR-HPV and LR-HPV compared with women with HR-HPV infection only, and the risk of progression of CIN2 is low in women with combined infection of HR-HPV and LR-HPV, though in this situation, HPV16 infection still remained high potential of progression . These findings may be useful for clinical management of women diagnosed with CIN2.
Dr Masao Okadome
National Kyushu Cancer Center
Read the Original
This page is a summary of: Potential impact of combined high- and low-risk human papillomavirus infection on the progression of cervical intraepithelial neoplasia 2, Journal of Obstetrics and Gynaecology Research, October 2013, Wiley,
DOI: 10.1111/jog.12202.
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