Differential Expression of RFamide-Related Peptide, a Mammalian Gonadotrophin-Inhibitory Hormone Orthologue, and Kisspeptin in the Hypothalamus of Abadeh Ecotype Does During Breeding and Anoestrous Seasons

  • M. R. Jafarzadeh Shirazi, M. J. Zamiri, M. S. Salehi, S. Moradi, A. Tamadon, M. R. Namavar, A. Akhlaghi, K. Tsutsui, A. Caraty
  • Journal of Neuroendocrinology, March 2014, Wiley
  • DOI: 10.1111/jne.12137

What is it about?

Gonadotrophin-inhibitory hormone (GnIH) is a novel hypothalamic neuropeptide that was discovered in birds as an inhibitory factor for gonadotrophin release. RFamide-related peptide (RFRP) is a mammalian GnIH orthologue that inhibits gonadotrophin synthesis and release in mammals through actions on gonadotrophin-releasing hormone (GnRH) neurones and gonadotrophs, mediated via the GnIH receptor (GnIH-R), GPR147. On the other hand, hypothalamic kisspeptin provokes the release of GnRH from the hypothalamus.

Why is it important?

Goat, a short-day seasonal breeder , is an excellent animal model for understanding the interaction of RFRP and kisspeptin for optimal reproductive functioning.

Read Publication


The following have contributed to this page: Dr Mohammad Reza Namavar