Differential Expression of RFamide-Related Peptide, a Mammalian Gonadotrophin-Inhibitory Hormone Orthologue, and Kisspeptin in the Hypothalamus of Abadeh Ecotype Does During Breeding and Anoestrous Seasons

M. R. Jafarzadeh Shirazi, M. J. Zamiri, M. S. Salehi, S. Moradi, A. Tamadon, M. R. Namavar, A. Akhlaghi, K. Tsutsui, A. Caraty
  • Journal of Neuroendocrinology, March 2014, Wiley
  • DOI: 10.1111/jne.12137

What is it about?

Gonadotrophin-inhibitory hormone (GnIH) is a novel hypothalamic neuropeptide that was discovered in birds as an inhibitory factor for gonadotrophin release. RFamide-related peptide (RFRP) is a mammalian GnIH orthologue that inhibits gonadotrophin synthesis and release in mammals through actions on gonadotrophin-releasing hormone (GnRH) neurones and gonadotrophs, mediated via the GnIH receptor (GnIH-R), GPR147. On the other hand, hypothalamic kisspeptin provokes the release of GnRH from the hypothalamus.

Why is it important?

Goat, a short-day seasonal breeder , is an excellent animal model for understanding the interaction of RFRP and kisspeptin for optimal reproductive functioning.

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The following have contributed to this page: Dr Mohammad Reza Namavar