What is it about?
alpha-Synuclein (aSyn) possesses neurotoxicity toward brain neuronal plasma membranes exposed directly to extracellular alpha-synuclein oligomers. Extracellular oligomeric α-synuclein rapidly associates to hippocampal membranes and induces pore formation in the hippocampal cells. This increases membrane conductance and calcium influx. Oligomeric α-synuclein also induces changes in synaptic current activity in hippocampal neurons. This data support the pathogenic role of extracellular aSyn in the brain, and provide a new strategy for the treatment of Parkinson's disease and other synucleinopathies, neurodegenerative diseases with aberrant accumulation of aggregated aSyn in neurons, nerve fibers or glial cells.
Featured Image
Why is it important?
It explains the mechanism of aSyn implication in neurodegeneration
Perspectives
Read the Original
This page is a summary of: Effect of α-synuclein on membrane permeability and synaptic transmission: a clue to neurodegeneration?, Journal of Neurochemistry, March 2015, Wiley,
DOI: 10.1111/jnc.13045.
You can read the full text:
Contributors
The following have contributed to this page