Effect of α-synuclein on membrane permeability

What is it about?

alpha-Synuclein (aSyn) possesses neurotoxicity toward brain neuronal plasma membranes exposed directly to extracellular alpha-synuclein oligomers. Extracellular oligomeric α-synuclein rapidly associates to hippocampal membranes and induces pore formation in the hippocampal cells. This increases membrane conductance and calcium influx. Oligomeric α-synuclein also induces changes in synaptic current activity in hippocampal neurons. This data support the pathogenic role of extracellular aSyn in the brain, and provide a new strategy for the treatment of Parkinson's disease and other synucleinopathies, neurodegenerative diseases with aberrant accumulation of aggregated aSyn in neurons, nerve fibers or glial cells.

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Why is it important?

It explains the mechanism of aSyn implication in neurodegeneration

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