GSK-3β activation index and recurrent inflammation of chronic rhinosinusitis without nasal polyps

What is it about?

In this study, we provided the first evidence that GSK-3α and 3β was highly expressed in both normal and CRSsNP nasal mucosa. Moreover, we found that the GSK-3β activation index (GSK-3β/p-GSK-3β) was significantly correlated with NF-κB protein level in CRSsNP group, which may be a potential indicator for recurrent inflammation of CRSsNP.

Featured Image

Why is it important?

These findings therefore expand our understanding on the pathogenesis of CRSsNP and demonstrate their potential use as therapeutic interventions.

Perspectives