What is it about?

A novel antibacterial peptide from Crocodylus siamensis hemoglobin hydrolysate (CHHs) was characterised for antimicrobial activity. The QAIIHNEKVQAHGKKVL fragment of Crocodylus siamensis hemoglobin is antibacterial via a mechanism that likely relies on iron dysregulation and oxidative stress which results in bacterial death. We have described for the first time, a novel peptide derived from Crocodylus siamensis hemoglobin hydrolysate, that has the potential to be developed as a novel antimicrobial peptide.

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Why is it important?

We have described for the first time, a novel peptide derived from Crocodylus siamensis hemoglobin hydrolysate, that has the potential to be developed as a novel antimicrobial peptide.

Perspectives

Writing this article was an awesome pleasure for me as a first author and all of co-authors as well. We are described for the first time that natural resource hemoglobin hydrolysate derived from Siamese crocodile (Crocodylus siamensis) could be developed as a new therapeutic agent for treating bacterial infection.

Dr Jiraporn Lueangsakulthai
Oregon State University

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This page is a summary of: A novel antibacterial peptide derived from Crocodylus siamensis haemoglobin hydrolysate induces membrane permeabilization causing iron dysregulation, oxidative stress and bacterial death, Journal of Applied Microbiology, September 2017, Wiley, DOI: 10.1111/jam.13539.
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