What is it about?
We hypothesized that an active lifestyle reflected in higher VO2max may be associated with greater SC number. As training alters basal p38-mitogen-activated protein kinase (MAPK) activity, which is associated with SC proliferation, SC count may also correlate with this stress signaling kinase.
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Why is it important?
SC number is proportional to VO2max, and hence it can be postulated that higher levels of physical activity activate SC proliferation but not fusion, underlining the relevance of exercise in stimulating SC pool size even without injury.
Perspectives
This investigation demonstrated that from a public health perspective, general fitness should help to maintain progenitor cell potential for rapid activation in response to future skeletal muscle stressors.
Dr Mari van de Vyver
Stellenbosch University
Read the Original
This page is a summary of: Satellite cell count, VO2max, and p38 MAPK in inactive to moderately active young men, Scandinavian Journal of Medicine and Science in Sports, September 2011, Wiley,
DOI: 10.1111/j.1600-0838.2011.01389.x.
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