What is it about?
Noninvasive measurement of His bundle magnetic fields (~ 100-200 femto Tesla) using SQUID-based Magnetocardiography (MCG) operating inside a shielded room.
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Why is it important?
As opposed to the conventional invasive catheter-based Electrophysiolgical (EPS) recordings of His bundle signals, the MCG-based noninvasive measurements are shown to be useful by a novel signal-averaging procedure which uses the QRS-onset as a fiducial point for averaging.
Perspectives
Such noninvasive measurements of His signals have been demonstrated by several work groups in ECG as well as MCG. However, the reliability of such noninvasive procedures are ensured by using QRS-onset as a fiducial point for avergaing several cardiac beats to improve the SNR of the as measured MCG/ECG signals to unravel ~femto Tesla level of signals undermined by background noise in the PR segment of the cardiac cycle. These noninvasive measurements are reasonable for cases where invasive gold-standard EPS measurements could not be easily justified for example on healthy individuals whose His-Purkinje electrical activity is to be characterized, and for infants suspected to have prolonged HV intervals and as a pre-EPS procedure, these noninvasive signal averaging measurements could be used.
Sengottuvel Senthilnathan
Indira Gandhi Center for Atomic Research, Kalpakkam, TN, India
Read the Original
This page is a summary of: Enhancing the Reliability in the Noninvasive Measurement of the His Bundle Magnetic Field Using a Novel Signal Averaging Methodology, Annals of Noninvasive Electrocardiology, July 2012, Wiley,
DOI: 10.1111/j.1542-474x.2012.00523.x.
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