What is it about?
Nitric oxide (NO) releasing drugs are a novel class of effective and safe agents for cervical ripening. We have used isosorbide dinitrate donor to induce cervical ripening of women with missed abortions before surgical evacuation of the uterus.
Featured Image
Why is it important?
The NO donor, isosorbide mononitrate, is effective at inducing cer-vical ripening during the first trimester, prior to medical termination of pregnancy. Two significant findings are that: 1) intracervical administration of 80 mg isosorbide dinitrate in women with missed abortions appears to be effective than misoprostol for cervical ripening prior to surgical evacuation of the uterus, and 2) we identify differences in the incidence of non‐serious adverse events are not likely to be clinically significant.
Perspectives
It is worth considering an important point about world wide safety of abortion and the indiscriminate use of abortive drugs. Beyond trying to understand the final outcome of ourselve procedure and the safety of abortion, the increased availability of misoprostol and the abortion-based telemedicine sketches that reach more women around the world may result in fewer women undergoing safe abortions with methods invasive outside health care systems. This view provokes the need to reconsider the use of new novel abortive drugs and way in which the abortive drugs should be registrated and distributioned, as well as, the adequate medical evaluation of the benefits and risks of the use of these drugs in safe and unsafe abortions.
Dr Gabriel Arteaga-Troncoso
National Institute of Perinatology
Read the Original
This page is a summary of: Intracervical application of the nitric oxide donor isosorbide dinitrate for induction of cervical ripening: a randomised controlled trial to determine clinical efficacy and safety prior to first trimester surgical evacuation of retained products of co..., BJOG An International Journal of Obstetrics & Gynaecology, December 2005, Wiley,
DOI: 10.1111/j.1471-0528.2005.00760.x.
You can read the full text:
Contributors
The following have contributed to this page
