What is it about?
To evaluate the A to C nucleotide change located 202 bp upstream to the transcription start site, (-202 A/C polymorphism), in the insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) gene, and its association with renal carinogenesis and with clinicopathological characteristics.
Photo by Ani Kolleshi on Unsplash
Why is it important?
Renal cell carcinoma (RCC) is the third leading cause of death among urological tumours. Insulin-like growth factors (IGFs) regulate cellular proliferation and differentiation. IGFB proteins (IGFBPs) regulate the action of IGFs. Polymorphism of the IGFBP-3 gene affects mean circulating IGFBP-3 concentrations. In this study, the AA genotype was significantly higher in patients with RCC than in controls. In addition, IGFBP-3 serum level was significantly higher in carriers of the A allele compared with non-carriers.
Read the Original
This page is a summary of: Insulin-like growth factor binding protein-3 (IGFBP-3) gene variants are associated with renal cell carcinoma, BJU International, February 2011, Wiley, DOI: 10.1111/j.1464-410x.2010.10017.x.
You can read the full text:
The following have contributed to this page