What is it about?
To investigate the possible relationships between premature ejaculation (PE) polymorphisms in the dopamine transporter (DAT) gene (SLC6A3, DAT1), which has a polymorphic 40 base pair (40 bp) variable number of tandem repeats (VNTR) sequence in the 3'-untranslated region (3' VNTR).
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Why is it important?
Premature ejaculation (PE) is the most prevalent male sexual dysfunction, affecting up to 31% of men aged 18–59 years. Although some psychological, behavioural and biological aetiologies have been proposed, the exact pathophysiology of PE has not yet been clearly understood. The process of ejaculation is greatly influenced by genetic and neurobiological factors. Familial predisposition to PE was first reported by Schapiro in 1943. Waldinger et al . reported that 10 of 14 first-degree relatives of men with lifelong PE also experienced PE. As a result, the aetiology of PE is based on a genetic predisposition.
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This page is a summary of: Relationship between premature ejaculation and genetic polymorphisms of the dopamine transporter gene (SLC6A3), BJU International, November 2010, Wiley, DOI: 10.1111/j.1464-410x.2010.09809.x.
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