What is it about?
Airway hyperresponsiveness is the main feature of asthma and also exists in cigarette smokers. In previous studies we have shown increased airway responsiveness to isoprenaline in asthmatic patients and smokers. In this study, tracheal responsiveness to isoprenaline and β-adrenergic receptor blockade was investigated in animals exposed to cigarette smoke (AECS) with or without sensitization by ovalbumin (OA).
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Perspectives
The results of this study indicate an increased tracheal response to a β2-adrenergic stimulating drug and enhanced β2-adrenergic blockade by propranolol. These results suggest similar increase in airway responsiveness to β2-adrenergic agonists and β2-receptor blockade in AECS and AECS + sensitized guinea pigs.
Dr Mohammad Reza Aslani
Ardabil University of Medical Sciencese
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This page is a summary of: Tracheal responsiveness to both isoprenaline and beta2-adrenoreceptor blockade by propranolol in cigarette smoke exposed and sensitized guinea pigs, Respirology, September 2006, Wiley,
DOI: 10.1111/j.1440-1843.2005.00893.x.
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