What is it about?
In order to elucidate the chronological morphological changes of the corpus luteum (CL) of rats, as a physiological angiogenesis model, the CL of rat ovaries was studied light microscopically using periodic acid methenamine silver staining (PAM) and immunostaining for type IV collagen, laminin, thrombomodulin (TM), factor VIII related antigen (factor VIII) and alpha-smooth muscle actin (alpha-SMA).
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Why is it important?
It is concluded that the angiogenesis of the CL begins at the time of destruction of the BM of the ovarian follicle, and that the capillary BM appears when the capillary forms its lumen. Moreover, it was demonstrated that the capillary does not develop into an arteriole during luteinization.
Perspectives
The ultrastructure of angiogenesis in luteinization should be elucidated.
Mr Takashi Matsushima
Nippon Medical School Musashikosugi Hospital
Read the Original
This page is a summary of: Neovascularization of the corpus luteum of rats during the estrus cycle, Pathology International, June 1996, Wiley,
DOI: 10.1111/j.1440-1827.1996.tb03631.x.
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