Antidermatophytic effects of NSAIDs on Trichophyton mentagrophytes and Epidermophyton floccosum

What is it about?

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most common pharmacological agents. They have three primary therapeutic properties including anti-inflammatory, anti-pyretic and analgesic effects. Seven NSAIDs were tested against two species of dermatophytes. Percentage inhibition was determined for effective agents. Diclofenac, aspirin and naproxen showed more potential to inhibit the growth of dermatophytes. Epidermophyton floccosum revealed susceptibility to more number of the tested agents than Trichophyton mentagrophytes. In conclusion, many NSAIDs may have a high potential to inhibit the growth of dermatophytes, while some of the agents belonging to this pharmaceutical group used in this study showed a potential activity on tested fungi.

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Why is it important?

NSAIDs agents are not clearly proved their antifungal action. Thus, successful results of the current research about the potent activity of some of NSAIDs on dermatophytes could be add a new function of these drugs, in addition to anti-inflammatory action

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