What is it about?
It discusses a tissue homeostatic view of what the immune system is doing. It questions whether the immune system's "attack" on micro-organisms is a direct attack or an attempt to restore homeostasis. The change in perspective is important.
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Why is it important?
Viewing the immune system as a bug hunting, chasing and killing mechanism blinds us to a more enlightening perspective of what the immune system is about.
Perspectives
Eventually, this series of articles leads to Copernican style revolution in perspective. We go from a lympho-centric view (adaptive immunity is at the core and in control) to an inflammo-centric view (inflammation, with its innate mechanisms, is at the core and in control). Adaptive immunity can now be viewed as a memory of prior inflammatory events.
Dr Jamie Cunliffe
Independant
Read the Original
This page is a summary of: Tissue Homeostasis and Immunity – More on Models, Scandinavian Journal of Immunology, September 2006, Wiley,
DOI: 10.1111/j.1365-3083.2006.01814.x.
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