What is it about?
Several endocrine and sexual disturbances have been demonstrated in multiple sclerosis (MS) patients of both sexes. The endocrine profile, hypothalamic–pituitary–testis (HPT) axis and semen quality were evaluated in male patients with MS. A total of 68 male MS patients aged 18 years or older were recruited. Forty-eight age-matched healthy male volunteers served as controls
Photo by Claudia on Unsplash
Why is it important?
Multiple sclerosis (MS) is one of the most common causes of chronic neurological disability in young and middle-aged adults. It affects more than 2 million people in the world. MS is characterised pathologically by perivascular inflammation, demyelination and axonal loss in the central nervous system (CNS). MS affects women two to three times more than men. However, the clinical progression of MS is more rapid and severe in men. MS patients have significant altered hormonal milieu. Disturbed neuroendocrine function may be involved in the pathogenesis and course of autoimmune diseases including MS. MS patients have reduced levels of growth hormone in the cerebrospinal fluid (3). Demyelinating lesions in the hypothalamus may cause a transient increase of antidiuretic hormone secretion and result in syndrome of inappropriate secretion of antidiuretic hormone.
Read the Original
This page is a summary of: Evaluation of Endocrine Profile, Hypothalamic-Pituitary-Testis Axis and Semen Quality in Multiple Sclerosis, Journal of Neuroendocrinology, October 2008, Wiley, DOI: 10.1111/j.1365-2826.2008.01791.x.
You can read the full text:
The following have contributed to this page