What is it about?
Innate immunity is a crucial system to protect against infection however, when it goes wrong it can led to life-threatening disease. Here we review the literature on when the innate immune system goes wrong in the lung, and how recognising the role aberrant innate immunity has in lung inflammation may lead to new therapeutic targets.
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Why is it important?
Understanding and recognising the role aberrant innate immunity has in lung inflammation may lead to new therapeutic targets.
Perspectives
Writing this article was a hugely enjoyable and informative. My co-authors and I have had long standing interest in autoinflammation and how the innate immune system is often overlooked in many diseases. This article challenges dogmas regarding well-studied diseases such as rheumatoid arthritis and cystic fibrosis, suggesting they are towards the autoinflammatory end of the immunological disease spectrum.
Thomas Scambler
University of Leeds
Read the Original
This page is a summary of: Autoinflammatory disease in the lung, Immunology, May 2018, Wiley,
DOI: 10.1111/imm.12937.
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