What is it about?
Human alveoli conains sialyl N-glycans and they are involved as the receptors for human, avian and other animal influenza viruses.
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Why is it important?
We identified the sialyl N-glycans found in human alveoli and characterized the influenza viruses that preferentially bound to these different structures. We also determined that amino acid changes in hemagglutinin that were linked to a switch of receptor-binding preference from nonhuman to pandemic, as well as pandemic to seasonal.
Perspectives
Our finding provide a better understanding of viral tropism and pathogenesis in humans that will be important for prediction and surveillance of zoonotic, pandemic and epidemic influenza outbreaks.
Yasuo Suzuki
Chubu University
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N
-glycan structures of human alveoli provide insight into influenza A virus infection and pathogenesis, FEBS Journal, April 2018, Wiley,
DOI: 10.1111/febs.14431.
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