What is it about?
PHIST proteins play important role in trafficking of PfEMP1-1 to iRBC surface. We have shown PHIST proteins localize to different sub cellular organelles inside iRBCs. We have reported that one of the PHISTc member PFD1140w localizes to maurer's cleft of iRBC and binds to both PfEMP-1 and PfSBP-1.
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Why is it important?
PHIST proteins in cytoadhesion and intracellular trafficking of the major virulent factor PfEMP-1 across the host cytosol. We propose that PFD1140w may bind both PfSBP-1 and PfEMP1 intracellular ATS segment to assist export of PfEMP-1 from the parasite to MCs, while PF11_0503 is likely to play a supportive role in cytoadhesion like its other surface-expressed counterparts.
Perspectives
I wish functional characterization of some members of PHISTc family proteins help in understand trafficking of exported proteins inside iRBCs.
Vikash Kumar
Guru Nanak Dev University
Read the Original
This page is a summary of: PHISTc protein family members localize to different subcellular organelles and bind Plasmodium falciparum
major virulence factor Pf
EMP-1, European Journal of Biochemistry, December 2017, Wiley,
DOI: 10.1111/febs.14340.
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