What is it about?
Understanding how peptides from fish eradicate bacteria.
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Why is it important?
New antibiotics are desperately needed due to the rise of antibiotic-resistant pathogens. By understanding how antimicrobial agents work we can design effective antimicrobial treatments in the future.
Perspectives
Writing this article was a great pleasure as it is our second product of a collaboration with Prof. Myriam Cotten (College of William and Mary), an expert on piscidins and biophysics. It is also a collaboration with Prof. Ruth Nussinov who focuses on understanding molecular interactions using computational approaches. By combining our efforts we were able to get a better picture on how these magnificent products of nature provide an effective defense against pathogens.
Professor Alfredo M Angeles-Boza
University of Connecticut
Read the Original
This page is a summary of: Nuclease activity gives an edge to host-defense peptide piscidin 3 over piscidin 1, rendering it more effective against persisters and biofilms, FEBS Journal, September 2017, Wiley,
DOI: 10.1111/febs.14263.
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