What is it about?
Methanogens use carbon sources other than hexoses due to their inability to transport carbohydrates. Therefore, gluconeogenesis is an essential pathway to synthesize macromolecules for biosynthetic purposes. We used biochemical approaches to determine metabolic and transcriptomic regulation of the gluconeogenesis, glycolysis as well the synthesis and degradation of glycogen in M. acetivorans.
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Why is it important?
Studies about ion of the central metabolism in Archaea organisms are still scarce.
Perspectives
This work may contribute in the understanding of the metabolic and transcriptomic control of the net flux of the pathways that helps in the cell homeostasis. These studies are scarce in organisms belonging to the Archaea Domain.
Dr Ricardo Jasso-Chavez
Instituto Nacional de Cardiologia Ignacio Chavez
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This page is a summary of: The nutritional status ofMethanosarcina acetivoransregulates glycogen metabolism and gluconeogenesis and glycolysis fluxes, FEBS Journal, April 2016, Wiley,
DOI: 10.1111/febs.13717.
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