What is it about?
This work shows the participation of brain angiotensin as a modulatory system in neuroadaptative responses to psychostimulant, that involve structural and nociceptive alterations.
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Why is it important?
We provided new evidences that extend the possible use of angiotensin receptor blockers as pharmacological tools in psychostimulants neurovascular detrimental effects. The protective effects of AT1 receptor antagonist are important since similar neurovascular alterations have been observed in mental disorders.
Perspectives
This is an integrative approach involving the three components of the neurovascular unit that gives support to the new perspective of the vascular role in brain disorders. Moreover, the present work support the brain angiotensin II role over multiple cellular types.
Claudia Bregonzio
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This page is a summary of: Neurovascular unit alteration in somatosensory cortex and enhancement of thermal nociception induced by amphetamine involves central AT1receptor activation, European Journal of Neuroscience, May 2017, Wiley,
DOI: 10.1111/ejn.13594.
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