What is it about?
The presence or absence of a functioning thyroid gland impacts on hypothalamic pituitary thyroid regulation
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Why is it important?
A declining thyroid function sensitises pituitary TSH response to circulating FT4 concentrations. FT3 in particular has an important role in this adjustement.
Perspectives
We propose a role for the quantitatively minor thyroidal co‐secretion of T3 with T4 in adjusting the central setting of thyroid control. This has practical consequences for the diagnosis and treatment of patients with impaired thyroid reserve.
Professor Rudolf Hoermann
Read the Original
This page is a summary of: The role of functional thyroid capacity in pituitary thyroid feedback regulation, European Journal of Clinical Investigation, August 2018, Wiley,
DOI: 10.1111/eci.13003.
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