What is it about?
The mixture methylchloroisothiazolinone (MCI)/ methylisothiazolinone (MI) is a well-known contact sensitizer. However, studies to determine the primary sensitizer in this blend are rare, and have been performed only in small groups of patients. In this article we conducted a larger study on humans in which we used the structure–activity relationship of the molecules to explain (i) why MCI is the stronger allergen, and (ii) why cross-reactivity between MCI and MI can be expected.
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Why is it important?
This large cohort study on patients with positive patch test reactions to MCI/MI suggests an original chemical approach for understanding the stronger sensitizing capacity of MCI and the possible but not frequent cross-reactivity between MCI and MI.
Perspectives
The presence of a sensitizing impurity, such as 4,5-dichloro-2-methyl-4-isothiazolin-3-one, or other decomposition by-products of the two molecules in the commercial raw materials should not be excluded.
Professor Luca Stingeni
Universita degli Studi di Perugia
Read the Original
This page is a summary of: An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact sensitivity: understanding the structure-activity relationship, Contact Dermatitis, March 2018, Wiley,
DOI: 10.1111/cod.12935.
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