What is it about?
The aim of the study was to examine the effects of preferential agonists of dopamine D3 receptors: pramipexole and 7-OH-DPAT on the harmaline-induced tremor in rats (a model of essential tremor, ET) measured in fully automated force plate actimeters. Both compounds reduce the harmaline-induced tremor, (a good model of ET) but only at low not higher doses. Blockade of dopamine D2 or D3 receptors did not reverse the tremorolytic effect of pramipexole and 7-OHDPAT.
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Why is it important?
The present study indicates that pramipexole, the well-known antiparkinsonian drug, reduces the harmaline-induced tremor, which may suggest its beneficial effects in ET patients. However, mechanisms underlying its action are still unclear and need further examination.
Perspectives
This study is important because showed the tremorolytic effect of pramipexole, the well-known antiparkinsonian drug. Essential tremor (ET) is one of the most common motor disorders in humans, current medications for which are still limited and only partially effective. Moreover, pathophysiological mechanisms underlying ET are complex and poorly understood. Therefore such experiments may help to understand the pathophysiology of this disease and to find the new therapy for it.
Jadwiga Wardas
Read the Original
This page is a summary of: Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats, CNS Neuroscience & Therapeutics, October 2015, Wiley,
DOI: 10.1111/cns.12467.
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