What is it about?
Amoeba is a human gut parasite which causes dysentery upon infection. Motility of parasite help in spreading the infection within the gut and other organs. We have explained the molecular mechanism for the mode of motility of Amoebic parasite during infection in the human gut.
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Why is it important?
Motility of Amoebic parasite helps to escape from immune responses of the body. Motility is also one of the important factor for spreading the infection to other organs which make it life threatening to the patient. we have explained the molecules which involve in regulation of motility of amoeba and these molecules may use as drug targets in future.
Perspectives
Plasma membrane blebs are less studied in respect of motility. Amoebic motility plays important in parasitic invasion and spreading the infection. We have found that blebs participate majorly in providing motility during infection within the gut. Lipids constitution of plasma membrane affects its rigidity. we have discovered the EhRho1 regulates lipid dynamics by regulating phosphoinositol 3 kinases in amoeba and in this way it controls the bleb formation and motility of parasite.
Ravi Bharadwaj
Jawaharlal Nehru University
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This page is a summary of: EhRho1 regulates plasma membrane blebbing through PI3 kinase in Entamoeba histolytica
, Cellular Microbiology, June 2017, Wiley,
DOI: 10.1111/cmi.12751.
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