What is it about?
In this paper, we have shown that dengue NS1 induced IL-10 production by monocytes, thereby contributing to disease pathogenesis.
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Why is it important?
We and others have found that IL-10, which a potent immunosuppresive cytokine is associated with severe dengue. We subsequently found that IL-10 suppressed dengue specific T cells responses in acute infection. Since NS1 alone appears to induce IL-10 production by monocytes, this viral protein is possibly causing disease pathogenesis by inhibiting virus specific T cell responses as an immune evasion strategy.
Perspectives
Although the pathogenesis of dengue was thought to be mainly due to an aberrant immune response to the virus, the virus itself appears to be a directly inducing an immunosuppresive environment as a immune escape mechanism.
Professor Gathsaurie Neelika Malavige
University of Sri Jayewardenepura
Read the Original
This page is a summary of: Dengue NS1 antigen contributes to disease severity by inducing interleukin (IL)-10 by monocytes, Clinical & Experimental Immunology, January 2016, Wiley,
DOI: 10.1111/cei.12747.
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