What is it about?
Thieno[2,3-d]pyrimidines as adenosine A2A and A3 receptors antagonists
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Why is it important?
Adenosine A2A receptor antagonists can be developed as promising therapeutic agents for the treatment of Parkinson's Disease, whereas adenosine A3 receptor antagonists as promising anti-cancer and anti-asthmatic agents.
Perspectives
First of all, it was a great privilege and learning experience of working in collaboration with pioneer scientist of this research area like Prof. KN Klotz. Secondly, we are the first research group to report novel thieno[2,3-d]pyrimidine derivatives as selective antagonists of A2A and A3 adenosine receptors. We believe further optimization of this scaffold would lead to the discovery and development of more potent antagonists.
Pran Kishore Deb
Faculty of Pharmacy, Philadelphia University, Jordan
Read the Original
This page is a summary of: Synthesis, adenosine receptor binding and molecular modelling studies of novel thieno[2,3-d
]pyrimidine derivatives, Chemical Biology & Drug Design, December 2017, Wiley,
DOI: 10.1111/cbdd.13155.
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