Analysis of residue conformations in peptides in Cambridge structural database and protein-peptide structural complexes

What is it about?

First of its kind analysis of properties which define the flexibility of peptide chains in biological context. This is the first step to integrate structural and conformational features of amino acid residues from Cambridge Structural Database and Protein Data Bank.

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Why is it important?

It is an important advance in the area with implications for peptide design. From the observations and conclusions of the work, it is clear that amino acid residues in peptide chains (when interacting with partner proteins), have shared correlations of geometric parameters which describe their flexibility/rigidity. This could help in positive/negative design of peptide inhibitors of protein-protein interactions.