What is it about?
Celastrol is a FANCD2 inhibitor that could interfere with the monoubiquitination and protein stability of FANCD2
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Why is it important?
Our results provide a novel opportunity to develop FA pathway inhibitor and combinational therapy for malignant neoplasms.
Read the Original
This page is a summary of: Celastrol induces proteasomal degradation of
FANCD
2 to sensitize lung cancer cells to
DNA
crosslinking agents, Cancer Science, May 2015, Wiley,
DOI: 10.1111/cas.12679.
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