Transient receptor potential vanilloid 1 inhibitors block laparotomy‐ and opioid‐induced infarct size reduction in rats

What is it about?

In response to the opioid epidemic, there is a shift in medical practice to use non-opioid pain medications in order to limit opioid administration during surgery. In rodents, we show that myocardial infarct size reduction conferred by an incision to the abdomen or morphine delivery is mediated by transient receptor potential vanilloid 1 (TRPV1). We show giving TRPV1 inhibitors may impede organ protection which is a potential limitation of developing TRPV1 inhibitors as analgesics for use during surgery.

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