Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac

What is it about?

We show that cyclic AMP can protect heart against ischaemic insult. This effect, along with an increased contractility of the heart, is mediated by a coordinated action of the two enzymes, PKA and Epac. Another enzyme, PKC, is activated by PKA and Epac and participates in the cyclic AMP-induced cardioprotection.

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