What is it about?
The current study was conducted to test the hypothesis that vascular dysfunction in obesity can be reversed by in vivo improvement of PVAT eNOS activity.
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Why is it important?
The study suggests that the reason for vascular dysfunction in obesity is not body weight itself but a PVAT dysfunction.
Perspectives
PVAT plays a key role in vascular dysfunction in diet-induced obese mice. Improving PVAT function by pharmacological means (e.g. with WS® 1442) can ameliorate vascular function even without reducing body weight or fat mass.
Huige Li
Johannes Gutenberg Universitat Mainz
Read the Original
This page is a summary of: Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight, British Journal of Pharmacology, January 2017, Wiley,
DOI: 10.1111/bph.13703.
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