Sperm Retrieval Rates in Azoospermia Factor C Microdeletion Patients: A Systematic Review

What is it about?

The study is a systematic review of 11 cohort studies reporting sperm retrieval rates (SRRs) in patients with azoospermia factor c (AZFc) microdeletions using microdissection testicular sperm extraction (mTESE). The overall SRR was 62.4%, with a wide range among studies. Older mean age and higher follicle-stimulating hormone (FSH) levels were associated with higher SRRs. The study suggests that patient factors need further investigation in future work.

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Why is it important?

This research is important because it provides valuable insights into the success rate of sperm retrieval in azoospermic patients with AZFc microdeletions through microdissection testicular sperm extraction (mTESE). Understanding the overall sperm retrieval rate (SRR) and its variations among studies can help guide clinicians in making informed decisions regarding the best treatment options for these patients. Key Takeaways: 1. The overall SRR of patients with AZFc microdeletion azoospermic was 62.4%. 2. The variation of SRRs among studies resulted in a wide range of SRRs from 25.0% to 85.7%. 3. Older mean age and higher mean FSH level were distinguishing features in those with SRRs higher than the overall value. 4. Testosterone levels had no evident association with the SRRs. 5. There is a need for further studies to confirm the predictive factors for SRRs in patients with AZFc microdeletions and to explore the exact predictive effects of FSH in these patients. 6. The exact reason for the low pregnancy rate and live-birth rate in azoospermic patients with AZFc microdeletions is not clear and needs further trials to explore and confirm.