Local Anaesthetic Transperineal Prostate Biopsy: A Systematic Review

What is it about?

This study aimed to assess the diagnostic ability, complication rate, patient tolerability, and cost of local anesthetic (LA) transperineal prostate biopsy. 35 publications with 113,944 men were included in the review. The cancer detection rate for LA transperineal prostate biopsy in patients undergoing primary biopsy was 52% and the clinically significant cancer detection rate was 37%. The rate of infection-related complications was 0.15%. LA transperineal procedures had a low rate of procedural abandonment. No formal cost analyses were identified in the literature. The overall risk of bias in the included studies was high, with considerable study heterogeneity and publication bias. The study concludes that further investigation into LA transperineal prostate biopsy with comparative studies is warranted for its consideration as the standard in prostate biopsy technique.

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Why is it important?

This research is important because it assesses the diagnostic ability, complication rate, patient tolerability, and cost of local anesthetic (LA) transperineal prostate biopsy. It is important because prostate cancer is the sixth most common cause of death from cancer in males worldwide, and biopsy of the prostate is the mainstay in the diagnosis of prostate cancer. It also helps to identify the advantages and disadvantages of LA transperineal biopsy compared to other biopsy techniques, which can aid in the decision-making process for healthcare providers and patients. Key Takeaways: 1. LA transperineal prostate biopsy has a cancer detection rate of 52% and a clinically significant cancer detection rate of 37% for patients undergoing primary biopsy. 2. LA transperineal biopsy has favorable infection and procedural abandonment rates, which demonstrate that it is relatively safe and tolerable for patients. 3. Theoretical cost comparisons for LA transperineal biopsy suggest that it is financially advantageous to adopt this technique, however, further practical data are required to support this claim. 4. Further investigation into LA transperineal prostate biopsy with comparative studies is warranted for its consideration as the standard in prostate biopsy technique.