Compositional analysis gives insight into leukaemia cell lines expression profiles compared to those within patient sub-groups

What is it about?

Cell lines are often used for laboratory studies but have been criticised for not being representative of the patient disease. This study has used the levels (known as expression levels) of RNA in different cell lines and mapping them back to large well defined patient data sets in which the expression levels had also been measured This allowed the cell lines to be mapped to a specific disease sub-type; and more importantly showed that cell lines with specific abnormalities mapped to the same patient disease sub-group.

Featured Image

Why is it important?

It will allow more confidence in results obtained from cell lines to be correlated back to disease sub-types in acute myeloid leukaemia