What is it about?
Mutational findings in the MPL gene are of diagnostic value in essential thrombocythaemia (ET) and primary myelofibrosis (PMF) without mutation in JAK2 or CALR. However, most focus has been on the two MPL mutations W515L and W515K. To extend the diagnostic benefit of mutational analysis, we have developed an assay which detects five MPL mutations in a single reaction.
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Why is it important?
The assay presented extends the mutational analysis of MPL. Since it is fast and easy to perform it is well suited for a clinical laboratory performing molecular diagnostics.
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This page is a summary of: Improved MPL
mutation screening with multiplex PCR and capillary electrophoresis, British Journal of Haematology, July 2016, Wiley,
DOI: 10.1111/bjh.14253.
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